Yeast Epigenetics

Yeast provides a flexible and rapid genetic system for studying cellular events. With an approximate generation time of 90 min, colonies containing millions of cells are produced after just 2 d of growth. In addition, yeast can propagate in both haploid and diploid forms, greatly facilitating genetic analysis. Like bacteria, haploid yeast cells can be mutated to produce specific nutritional requirements or auxotrophic genetic phenotypes, and recessive lethal mutations can either be maintained in haploids as conditional lethal alleles (e.g., temperature-sensitive mutants), or in hetero zygotic diploids, which carry both wild-type and mutant alleles.

Extremely useful is the efficient homologous recombination system of budding yeast, which allows the alteration of any chosen chromosomal sequence at will. In addition, portions of chromosomes can be manipulated and reintroduced on plasmids that are stably maintained through cell division, thanks to short sequences that provide centromere and replication origin function. Large linear plasmids, or minichromosomes, which carry telomeric repeats to cap their ends, also propagate stably in yeast. Yeast also has a unique advantage in the genetic analysis of histones and their roles in gene regulation.

Related Conferences

EMBL Conference: Chromatin and Epigenetics, 05/06/2017, Heidelberg (DE); Population Genomics of New and Emerging Fungal and Oomycete Diseases of Animals and Plants, 05/11/2017, Zurich (CH); 12th International Meeting on Yeast Apoptosis (IMYA12), 14-18 May 2017, Bari, Italy; Biotechnica 2017 – Biotechnology, Life Sciences and Lab Technology,16-18 May, Hannover (DE); European Biotechnology Congress 2017,25-27May, Dubrovnik (HR); Yeast Genetics Meeting August 22-26, 2018, Stanford, California; 2017 RNA Symposium April 14, 2017 Calit2 Auditorium (Building #325), UC Irvine; Mycological Diversity and Fungal Biology Montreal, Canada May 14 - 15, 2018

Related Associations

  • The Society for Pharmaceutical and Biotech Trainers,USA
  • European Federation of Pharmaceutical Industries and Associations
  • Japan Bioindustry Association
  • ASMUSA American Society for Microbiology
  • International Union of Microbiological Societies, USA
  • Society for Industrial Microbiology and Biotechnology (SIMB)
  • North Carolina Association for Biomedical Research
  • Society of Bioprocessing Professionals
  • The New York Biotechnology Association

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